TACTIC Coronary Thrombus Aspiration With Cath Rx In Anterior Myocardial Infarction: A Randomized … (NCT06887413) | Clinical Trial Compass
RecruitingNot Applicable
TACTIC Coronary Thrombus Aspiration With Cath Rx In Anterior Myocardial Infarction: A Randomized Control Trial.
Italy140 participantsStarted 2026-02-18
Plain-language summary
The aim of this study is to evaluate the impact of sustained thrombectomy with INDIGO ASPIRATION SYSTEM using CAT RX versus no thrombectomy during primary percutaneous coronary intervention (PPCI) on microvascular obstruction and infarct size, as measured by cardiovascular magnetic resonance (CMR) between 3 and 5 days post PPCI, in patients with anterior STEMI
Who can participate
Age range18 Years – 75 Years
SexALL
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Inclusion criteria
✓. Age \>18 and \<75 years old
✓. Acute anterior STEMI with ≥2 mm in two (2) or more contiguous anterior leads or ≥4 mm total ST-segment deviation sum in the anterior leads V1-V4 AND anterior wall motion abnormality noted on a diagnostic quality left ventriculogram or echocardiogram
✓. Culprit lesion proximal or mid LAD at coronary angiography
✓. TIMI thrombus grading \> 3 or TIMI flow 0 after guidewire crossing the lesion.
✓. Patient presents to the hospital between 1 - 6 hours of ischemic pain onset
✓. Patient indicated for primary percutaneous coronary intervention (PPCI)
Exclusion criteria
✕. Unable to give Informed consent.
✕. Life expectancy \< 1 year.
✕. Contraindication to PCI
✕. STEMI due to stent thrombosis
✕. Spontaneous coronary aretery dissection
✕. Patient undergone any kind of maneuvers to restore flow before randomization
✕. Unwitnessed cardiac arrest OR ≥30 minutes of cardiopulmonary resuscitation (CPR) prior to enrolment OR any cardiac arrest with impairment in mental status, cognition or any global or focal neurological deficit