Noradrenaline Versus Standard Blood Pressure Management for Perioperative Hypotension in Non-card… (NCT06885268) | Clinical Trial Compass
RecruitingPhase 3
Noradrenaline Versus Standard Blood Pressure Management for Perioperative Hypotension in Non-cardiac Surgery
Poland750 participantsStarted 2025-06-25
Plain-language summary
The effect of noradrenaline infusion versus standard blood pressure management on perioperative HYPotension in NOn-caRdiac surgery.
The study aims to determine whether perioperative noradrenaline infusion is superior to standard blood pressure management for the occurrence of perioperative hypotension.
Who can participate
Age range45 Years
SexALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
✓. ≥45 years old
✓. Elective or accelerated\* non-cardiac surgery expected to last ≥1 hour and requiring general, neuraxial, or combined general with neuraxial anesthesia
✓. Expected to stay overnight in the hospital after surgery
✓. Written informed consent to participate in the HYP-NOR Trial provided
✓. American Society of Anesthesiologists (ASA) physical status class II or higher.
Exclusion criteria
✕. Newly diagnosed, untreated, or uncontrolled hypertension -in two measurements on the day before surgery Systolic Blood Pressure (SBP) ≥180 mm Hg or Diastolic Blood Pressure (DBP) ≥110 mm Hg
✕. Persistent difference in recorded SBP between right and left upper limb \>10 mm Hg
✕. Persistent atrial fibrillation
✕. Have a documented history of dementia
✕. Have language, vision, or hearing impairments that may compromise cognitive assessments
✕. Have a condition that precludes routine blood pressure management such as surgeon request for relative hypotension
✕. Receiving irreversible nonselective monoamine oxidase inhibitors (e.g. tranylcypromine, phenelzine) within 2 weeks preceding study enrolment