Experimental Malaria Infection of Healthy Malaria-Naive Adults by Mosquito Bite With the Genetically Modified Plasmodium Falciparum NF54/iGP3 GAP

INCLUSION CRITERIA: * Able and willing to complete the informed consent process * Available for the entire planned study duration * Male or Female * Aged 18 to 55 years * Willing to have blood samples collected, stored indefinitely and used for research purposes * Willing to defer blood donations for at least six months after the EoS visit (D180) * Agreement to adhere to specific Lifestyle Considerations throughout study duration Clinical Criteria: * Total body weight ≥ 50 kg, and a body mass index (BMI) within the range of 18 to 32 kg/m2 (inclusive) * In good general physical and mental health as evaluated through a comprehensive clinical assessment * Vital signs at screening and pre-inoculation within normal clinical range * Electrocardiograph (ECG) without significant abnormalities, including: QTcF ≤450 ms for males, QTcF ≤470 ms for females, PR interval ≤210 ms Laboratory Criteria: * O negative blood type * Haemoglobin, white cell count and platelet levels within normal laboratory ranges * Ferritin, creatinine and alanine aminotransferase (ALT) within normal laboratory ranges * No clinically significant abnormality in coagulation or clotting * Normal G6PD enzyme activity levels as defined by the parameters of the specific quantitative G6PD test performed at screening * Negative for blood borne viruses, including Human Immunodeficiency Virus (HIV), Hepatitis B virus (HBV), Hepatitis C virus (HCV), Human T-lymphotropic virus type 1 (HTLV); and other blood borne pathoge…