This study focuses on rare brain tumors, which are heterogeneous entities with different morphological, biological, and clinical characteristics. Due to their rarity, many of these tumors fall under the RARECARE definition of rare tumors. The main objective of the study is to standardize care models and pathways for patients with rare brain tumors, using Artificial Intelligence (AI) and Machine Learning (ML) techniques to identify specific predictors of postoperative outcomes. The study includes both retrospective and prospective phases, with the collection of clinical, cognitive, and psychological data at various time points. Patients will undergo an early neuro-cognitive rehabilitation program using the RehaCom software, which will be conducted at home. The goal is to improve the quality of life and care for patients through a multidisciplinary and innovative approach.
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Symptoms/Signs Onset
Timeframe: Pre-operative
Karnofsky Performance Status (KPS)
Timeframe: 12 months.
Neurology Assessment in Neuro-Oncology (NANO)
Timeframe: From hospital admission until discharge
Modified Rankin Scale (mRS)
Timeframe: 12 months
American Society of Anesthesiologists (ASA)
Timeframe: Pre-operative
Charlson Comorbidity Index (CCI)
Timeframe: Pre-operative
Magnetic Resonance Imaging (MRI)
Timeframe: 12 months.
Eloquent Area Involvement
Timeframe: Intra-operative
Cranial Nerve Manipulation
GIORGIA CAMARDA, Master's degree
Timeframe: Intra-operative
Vascular Manipulation
Timeframe: Intra-operative
Extent of Resection
Timeframe: Post-operative immediate
Edema
Timeframe: Pre-operative
Deep Location
Timeframe: Pre-operative
Histology and Molecular Data
Timeframe: Post-operative
Preoperative Neurological Examination (EON)
Timeframe: Pre-operative
Tumor Side
Timeframe: during surgery
Tumor Location
Timeframe: pre-procedure
Cranial Nerve Status
Timeframe: pre-procedure
Cognitive Data Collection: Phonemic Verbal Fluency
Timeframe: 12 months.
Cognitive Data Collection: Semantic Verbal Fluency
Timeframe: 12 months.
Cognitive Data Collection:Token Test
Timeframe: 12 months.
Cognitive Data Collection: Digit Span Forward and Backward
Timeframe: 12 months.
Cognitive Data Collection: Rey 15-Word List
Timeframe: 12 months.
Cognitive Data Collection: Rey Figure Reproduction
Timeframe: 12 months.
Cognitive Data Collection: Modified Taylor Complex Figure
Timeframe: Pre-operative, follow-up at 3 and 12 months.
Cognitive Data Collection:Trail Making Test
Timeframe: Pre-operative, follow-up at 3 and 12 months.
Cognitive Data Collection: Stroop Test
Timeframe: 12 months.
Cognitive Data Collection: Mini-Mental State Examination (MMSE)
Timeframe: 12 months.
Cognitive Data Collection: Frontal Assessment Battery
Timeframe: 12 months.
Psychological and Quality of Life Data Collection: WHO Disability Assessment Schedule (WHODAS 2.0)
Timeframe: 12 months.
Psychological and Quality of Life Data Collection: European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30)
Timeframe: 12 months.
Psychological and Quality of Life Data Collection: European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire - Brain Neoplasms 20 (EORTC QLQ-BN20)
Timeframe: 12 months.
Psychological and Quality of Life Data Collection: Hospital Anxiety and Depression Scale (HADS)
Timeframe: 12 months.