Minimally Invasive Pelvic Exenteration in Vaginal or Cervical Cancer Recurrence

Inclusion Criteria: * Diagnosis of recurrent or persistent vaginal or cervical cancer * Proven histological diagnosis of squamous carcinoma, adenocarcinoma or adenosquamous carcinoma * Isolated central pelvic recurrence * MRI-measured maximum tumor diameter ≤ 50 mm * Age \> 18 years * Patients who have signed an approved informed consent form * Patients must be suitable for surgery * ECOG Performance Status of 0, 1 or 2 (Eastern Cooperative Oncology Group) Exclusion Criteria: * Para-aortic lymph nodes with a short-axis diameter ≥ 15 mm on MRI scan and/or SUV max ≥ 2.5 on PET/CT scan * Involvement of lateral pelvic structures (on preoperative imaging or during examination under anaesthesia) * Sciatic nerve involvement (at pre-operative imaging or during examination under anaesthesia) * Distant metastasis at PET/CT scan * Any histological type other than squamous carcinoma, adenocarcinoma, or adenosquamous carcinoma * Contraindications to surgery * Serious concomitant systemic disorders incompatible with surgery or minimally invasive surgery (at the discretion of the investigator) * Women unable to tolerate prolonged lithotomy and steep Trendelenburg positions * Women with secondary invasive neoplasm in the last 5 years