Single Cell Landscape of HBV-related Acute-on-chronic Liver Failure Patients (NCT06865859) | Clinical Trial Compass
UnknownNot Applicable
Single Cell Landscape of HBV-related Acute-on-chronic Liver Failure Patients
China21 participantsStarted 2023-11-01
Plain-language summary
This study aimed to profile the peripheral blood immune cells of patients with HBV related acute-on-chronic liver failure using single-cell RNA sequencing to reveal the immunopathological mechanisms of HBV related acute-on-chronic liver failure.
Who can participate
Age range18 Years
SexALL
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Inclusion Criteria:
Acute liver failure is a well-defned medical emergency which is defned as a severe liver injury, leading to coagulation abnormality usually with an INR ≥ 1.5, and any degree of mental alteration (encephalopathy) in a patient without pre-existing liver disease and with an illness of up to 4 weeks duration
Exclusion Criteria:
* Associated with other types of hepatitis virus infection or HIV infection, alcoholic liver disease, autoimmune liver disease, drug-induced liver injury; â‘¡ Suffering from primary liver cancer or severe heart, digestive, lung, kidney, neurological and psychiatric diseases; â‘¢ Patients with incomplete data and patients unable to participate in the experiment.