Perioperative Inhaled Therapy in Carcinological Thoracic Surgery in Patients at High Risk of Post… (NCT06865040) | Clinical Trial Compass
RecruitingNot Applicable
Perioperative Inhaled Therapy in Carcinological Thoracic Surgery in Patients at High Risk of Postoperative Pulmonary Complications
France266 participantsStarted 2025-07-31
Plain-language summary
The objective of the study is to evaluate, in a clinical trial, the efficacy of peri operative administration of long-acting inhaled ß-2 mimetics on the occurrence of postoperative pulmonary complications
Who can participate
Age range18 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Adult (\>18 years)
* Lung cancer eligible for surgical management by lung resection (non-small cell lung carcinoma = NSCLC) by any route
* Naïve to long-term inhaled bronchodilator therapy
* High risk of post-operative pulmonary complications (Pre-operative FEV1 \< 80%)
Exclusion Criteria:
* Patient refusal
* Pregnancy
* Emergency surgery
* Patient with a physiological status of WHO IV or ASA ≥ IV
* Asthma
* Patients treated with long-acting bronchodilators
* Severe heart failure (NYHA IV), unstable ischaemic heart disease (angina or recent infarction \< 3 months), obstructive hypertrophic cardiomyopathy, subvalvular aortic stenosis, severe uncontrolled hypertension Recent stroke \< 3 months
* High-grade unresponsive conductive disorders or unstable arrhythmia
* Thyrotoxicosis, pheochromocytoma
* Unbalanced diabetes
* Hypersensitivity to ß-2 mimetics or lactose
* Current participation in a trial of another drug therapy