A Cardiac Liability Study of Varegacestat in Healthy Participants (NCT06855264) | Clinical Trial Compass
CompletedPhase 1
A Cardiac Liability Study of Varegacestat in Healthy Participants
United States32 participantsStarted 2025-02-24
Plain-language summary
This clinical study is designed to study the effect of a single dose of varegacestat on cardiac repolarization in healthy adult participants.
Who can participate
Age range18 Years – 55 Years
SexALL
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Inclusion Criteria:
* Healthy, adult, male or female (of non childbearing potential), 18 to 55 years of age, inclusive, at the screening visit.
* Medically healthy with no clinically significant medical history, physical examination, clinical laboratory profiles, and vital signs, as deemed by the PI or designee
Exclusion Criteria:
* History of any illness that, in the opinion of the PI or designee, might confound the results of the study or pose an additional risk to the participant by their participation in the study.
* Have taken an investigational drug or participated in a clinical trial evaluating an investigational drug or device within 30 days (or 5 half-lives) prior to the study drug dose, whichever is longer.
What they're measuring
1
Placebo-corrected change from baseline QTc and varegacestat and its metabolite, AL102 MTB, plasma concentrations