SuspendedPhase 1/2

Premixed Glucagon/Insulin Solution for Faster Insulin Absorption in Type 1 Diabetes

Stopped: No sign of anticipated effect.

Norway30 participantsStarted 2025-04-01

Plain-language summary

We will investigate if Lyumjev premixed with nanogram amounts of glucagon speed up the absorption of insulin and the effect on whole body glucose consumption compared to native lyumjev in patients with type 1 diabetes. To do that we will perform euglycemic clamps investigations in patients meetinng fasting in the morning on two separate days.Frequent samples for glucose and insulin measuremenst will be drawn and the day with lyumjev only will be compared to the day with premixed Lyumjev.

Who can participate

Age range18 Years – 70 Years

SexALL

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Inclusion criteria

✓. T1D for at least one year.
✓. Age 18 - 70 years.
✓. Last known HbA1c \<75 mmol/mol (\< 9.0%).
✓. Treated with an insulin pump or a hybrid artificial pancreas (AP).

Exclusion criteria

✕. Pregnant women or women trying to conceive (women will not be screened by a pregnancy test).
✕. Any chronic disease, including psychiatric illnesses, judged incompatible with participation in the study.
✕. Unfit for participation for any reason as judged by the investigators.
✕. Known hypersensitivity to glucagon or to any of the excipients of the drug formulations.
✕. Known phaeochromocytoma.

What they're measuring

Area under the glucose consumption curve

Timeframe: First 30 minutes

Area under the insulin curve Area under the insulin curve

Timeframe: First 30 minutes

Trial details

NCT IDNCT06854861

SponsorSt. Olavs Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-11-30

View on ClinicalTrials.gov More Type 1 Diabetes trials