A Prospective Study of Cadonilimab in Hepatocellular Carcinoma After Radical Surgery With High Risk of Recurrence

Inclusion Criteria: * Sign a written informed consent before the implementation of any trial-related procedures. * Male or female, aged ≥18 years and ≤70 years. * ECOG PS score is 0 - 1 point. * Subjects diagnosed with hepatocellular carcinoma by imaging criteria and/or pathology and who have received curative resection. * The definition of curative resection complies with the definition of curativeness in the 2024 edition of the Chinese Guidelines for Primary Liver Cancer (CNLC). * The postoperative recurrence risk stratification conforms to the high - risk group in the ERASL - pre or ERASL - post formula. * No prior systemic antitumor treatment for hepatocellular carcinoma has been received. * Child - Pugh liver function score of grade A or B7. * Expected survival time \> 6 months. Exclusion Criteria: * Previously diagnosed by histology/cytology, including fibrolamellar hepatocellular carcinoma, sarcomatoid hepatocellular carcinoma, cholangiocarcinoma, etc. * Subjects with other malignant tumors within 5 years before enrollment, except for HCC. Subjects with other malignant tumors that have been cured by local treatment are not excluded, such as basal or squamous cell carcinoma of the skin, superficial bladder cancer, carcinoma in situ of the cervix or breast. * History of hepatic encephalopathy or liver transplantation. * Portal vein trunk or mesenteric superior vein, inferior vena cava tumor thrombus.