A First-in-human Study of HCR-188 in Overweight or Obese Otherwise Healthy Volunteers Without Type 2 Diabetes

Inclusion Criteria: * Body Mass Index (BMI) of 27 to 40 kg/m2, inclusive * Except for overweight or obese, otherwise healthy as determined by the Investigator * Stable body weight, defined as a \< 5 kg change during the 8 weeks prior to screening * Females of childbearing potential must agree to use highly effective methods of contraception during the participation in the study * Males must be surgically sterile, abstinent, or must agree to use highly effective methods of contraception during participation in the study Exclusion Criteria: * History of or active cardiovascular (CV) disease * History of active pulmonary diseases * History of immunosuppressive, chemotherapeutic, or radiation treatment within the last 12 months prior to Screening * History of malignancy in the past 12 months or active malignancy * History of bariatric surgery or use of gastric balloons * History of diabetes mellitus Type 1 or 2 * History of chronic liver disease * Pregnant or breastfeeding, or a positive pregnancy test at Screening * Treatment with medications that may cause significant weight gain or weight loss