Lesion Healing After Regenerative Endodontic Treatment
Turkey (Türkiye)30 participantsStarted 2024-01-01
Plain-language summary
Endodontics involves various therapeutic interventions for diagnosing, preventing, and managing pulpal and periradicular pathologies. Root canal treatment, a widely performed procedure, involves removing necrotic pulp tissue and replacing it with a root-filling material, but it limits the tooth's immune defense and regenerative capacity. In immature permanent teeth, pulpal damage can lead to incomplete root formation, increasing the risk of fractures. To address these challenges, regenerative endodontic procedures (REPs) promote tissue regeneration within the root canal using tissue engineering principles.
Despite high success rates, REPs lack a standardized irrigation protocol. Current guidelines recommend using 17% EDTA after low-concentration NaOCl to reduce cytotoxicity and release bioactive molecules. Citric acid has shown promise in in vitro studies as an alternative chelating agent, but direct comparisons with EDTA in clinical settings remain limited. This study aims to bridge this gap by evaluating the long-term effects of EDTA and citric acid on clinical symptoms and lesion healing in REPs.
Who can participate
Age range
9 Years – 15 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
The included patients were healthy (Category: American Society of Anesthesiologists class 1). This study included the necrotic, deeply carious mandibular molars of patients born between 2009 and 2015. Preoperative periapical films of the relevant teeth were evaluated, and teeth determined as Stages 2 and 3 according to the Cvek classification were included in the current study \[27\].
Exclusion Criteria:
* Patients were excluded if they had a systemic disease or were on systemic corticoste roid therapy, patients reported bruxism or clenching, took analgesics or other drugs that might alter their pain during the last 12 h preoperatively, or had a history of allergic reac tions to any of the medications or materials used. Patients with a tooth with severely curved root canals, vertical root fracture, coronal perforation, calcification or more signifi cant than Grade I mobility, or pocket depth greater than 5 mm were also excluded.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Comparison of the effects of different irrigation solutions used in regenerative endodontics on lesion healing using surveys