Contrast Enhanced Mammography in the Evaluation of Cancer of Unknown Primary Syndrome

Inclusion Criteria: * Age: Patients aged 18 years or older. * Diagnosis of CUP: Patients with a clinical diagnosis of Cancer of Unknown Primary (CUP) syndrome. * Suspected Breast Malignancy: Patients with clinical or imaging suspicion of a primary breast malignancy. * Informed Consent: Patients who are able to provide informed consent to participate in the study. * Presence of Breast Tissue: Female or transgender patients with breast tissue eligible for Contrast-Enhanced Mammography (CEM). Exclusion Criteria: * Confirmed Primary Tumor: Patients with a confirmed primary tumor identified in an organ other than the breast. * Contraindications to Contrast Agents: Patients with contraindications to the use of iodinated contrast agents (e.g., severe allergic reactions to contrast). * Severe Renal Impairment: Patients with severe renal impairment (eGFR \< 30 mL/min/1.73 m²) who cannot safely receive contrast agents. * Pregnancy or Breastfeeding: Pregnant or breastfeeding women, as contrast administration may be harmful to the fetus or neonate. * Severe Medical Conditions: Patients with severe medical conditions that may compromise their participation or safety in the study.