The purpose of this study is to evaluate the safety and immunogenicity of PCV21 versus 20vPCV ( 20-valent pneumococcal conjugate vaccine, Prevnar 20) for catch-up vaccination in infants (7 to 11 MoA-Months of age), toddlers (12 to 23 MoA), and children/adolescents (2 to 5 YoA and 6 to 17 YoA-years of age).
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Number of participants reporting immediate adverse events (AEs)
Timeframe: Within 30 minutes post-vaccination
Number of participants reporting solicited injection site and solicited systemic reactions
Timeframe: Up to Day 7 post-vaccination
Number of participants reporting unsolicited (spontaneously reported) injection site reactions and unsolicited systemic AEs after each and any injection of a pneumococcal vaccine
Timeframe: Within 30 days after vaccination
Number of participants reporting serious adverse events (SAEs) and adverse events of special interest (AESIs)
Timeframe: From day 0 to day 517
Number of Infants (7-11 months of age [MoA]) and toddlers (12-23 MoA): with serotype-specific IgG concentrations for all serotypes included in PCV21
Timeframe: On day 30 after last vaccination
Number of Children (2-5 years of age [YoA]):with serotype specific OPA titers for all serotypes included in PCV21
Timeframe: On day 30
Number of Children (2-5 years of age [YoA]):with serotype specific IgG concentrations for all serotypes included in PCV21
Timeframe: On day 30
Number of Children/adolescents (6-17 YoA):with serotype specific OPA titers for all serotypes included in PCV21
Timeframe: On day 30