The goal of this clinical trial is to see if silent brain infarcts (SBIs), or stroke-like symptoms detectable during brain imaging, are a possible contributor to cognitive decline for patients diagnosed with spontaneous intracerebral hemorrhage (sICH), or blood clot in the brain. The main questions it aims to answer are * if SBIs in sICH are associated with a lower cognitive level and more rapid cognitive decline * if SBIs in sICH are associated with certain findings on brain imaging * if SBIs in sICH are associated with higher inflammation measured by certain blood tests Participants will undergo * cognitive testing during hospitalization, and at 3, 6 and 12 months after the sICH * Magnetic Resonance Imaging (MRI) of the brain during hospitalization and 12 months after the sICH * blood draws during hospitalization and at 3, 6 and 12 months after the sICH
Age range
18 Years – 80 Years
Sex
ALL
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Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Global Cognition
Timeframe: From date of randomization and assessed throughout the during hospitalization for qualifying ICH event up to 12 months
Global Cognition
Timeframe: 3 months after hospitalization
Global Cognition
Timeframe: 6 months after hospitalization
Global Cognition
Timeframe: 12 months after hospitalization
Absolute volumetric change in White Matter Hyperintensity (WMH)
Timeframe: from MRI at hospitalization to MRI at 12 months
Serum soluble urokinase-type plasminogen activator receptor (suPAR) levels
Timeframe: From date of consent and assessed during hospitalization for qualifying ICH event up to 12 months
Serum soluble urokinase-type plasminogen activator receptor (suPAR) levels
Timeframe: 3 months after hospital discharge
Serum soluble urokinase-type plasminogen activator receptor (suPAR) levels
Timeframe: 6 months after hospital discharge
Serum soluble urokinase-type plasminogen activator receptor (suPAR) levels
Timeframe: 12 months after hospital discharge