Effect of Different Proprioceptive Neuromuscular Facilitation Techniques Versus Flow Trigger Sens… (NCT06831201) | Clinical Trial Compass
Not Yet RecruitingPhase 1
Effect of Different Proprioceptive Neuromuscular Facilitation Techniques Versus Flow Trigger Sensitivity on Weaning Off Mechanical Ventilation
Egypt84 participantsStarted 2025-02-20
Plain-language summary
Weaning is a critical stage in respiratory care, requiring strategies to optimize breathing muscle function and reduce patient dependence on ventilatory support.
PNF Techniques: These techniques are traditionally used to improve muscle strength and coordination. When applied to respiratory therapy, PNF can enhance diaphragmatic strength, improve chest wall mobility, and promote effective breathing patterns, potentially accelerating the weaning process.
Flow Trigger Sensitivity: This approach focuses on fine-tuning ventilator settings to ensure minimal patient effort in initiating breaths. By improving patient-ventilator synchronization, it reduces respiratory muscle fatigue and supports efficient weaning.
The study likely compares the two approaches in terms of weaning success rates, duration, and respiratory muscle performance. It may conclude that combining PNF techniques with optimized ventilator settings can improve weaning outcomes by enhancing respiratory muscle functionality and reducing mechanical ventilation dependency.
Who can participate
Age range18 Years – 80 Years
SexALL
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Inclusion criteria
✓. Eighty four mechanically ventilated ICU patients under supervision; their age will be above 18 years old.
✓. Mechanically ventilated due to type 1 or type 2 respiratory failures (RF) for at least 24 hours and Candidate for early extubation.
✓. All patients are conscious and co-operative
✓. All patients able to participate in training actively, weanable as regard to readiness weaning
✓. All patients are hemodynamically stable.
✓. Patient will be assigned in to three groups.
✓. Presence of weaning criteria as defined in the European consensus conference in 2007, including sedation reduction, spontaneous breathing cycles, partial pressure of oxygen (PaO2)/fraction of inspired oxygen (FiO2)150, absence of inotropes or vasopressors at high doses or increasing doses ( 1 mg/h),oxyhaemoglobin saturation (SaO2) 90% with FiO2 50% , positive end expiratory pressure (PEEP) 8 cmH2O,temperature is less than 38 ◦C.
Exclusion criteria
✕. Hemodynamic or respiratory instability.
What they're measuring
1
Maximum inspiratory pressure (MIP )
Timeframe: 10 days
2
Weaning success
Timeframe: 10 days
Trial details
NCT IDNCT06831201
SponsorBeni-Suef University
Sponsor typeOTHER
Study typeINTERVENTIONAL
Primary completion2025-03-20
Contact for this trial
Prof. Dr. Sherin Hassan Mehani, Professor of Physical Therapy