Study on the Efficacy of Endoscopic Radiofrequency Treatment in Reducing the Need for Blood Transfusions in GAVE

Inclusion Criteria: * At least 18 years of age * Existing diagnosis of GAVE (validated by an external expert) * Melena and/or hematemesis secondary to GAVE and/or iron deficiency anemia persisting despite systemic iron therapy or oral supplementation and/or (concentrated red globules) GRC transfusions for at least 6 months * Negative colonoscopy (performed within 12 months prior to enrollment, exclusion of any site of bleeding) * Able to comply with study requirements and understand and sign the informed consent form Exclusion Criteria: * Alternative causes for iron deficiency anemia (gastro-duodenal erosions and/or ulcerations, celiac disease, Inflammatory Bowel Disease (IBD), etc) * Pregnancy * Active malignancy (malignancy diagnosed in past five years or ongoing treatment) * Anatomical malformations precluding treatment with RFA * Blood coagulation deficit: International normalized ratio (INR)\>2, Platelets (PLT) \<50,000