Study of the Prevalence of Endogenous Hypercortisolism in Patients With Resistant Hypertension (MOMENTUM)

Inclusion Criteria: * Each patient must meet all of the following criteria to be enrolled in the study: * Signed and dated Institutional Review Board (IRB)-approved informed consent form (ICF) prior to any study-specific screening procedures. * Male/female patients must be 18 years or older at the time of signing the informed consent. * Meet either of the following criteria: * Has rHTN, defined by the American Heart Association as BP above target (systolic ≥ 130 mmHg for purposes of this study) despite concurrent use of 3 or more antihypertensive medications from different classes at their maximally tolerated doses, and 1 of these agents is a diuretic. * Or, has rHTN, defined by the American Heart Association as SBP at target or above target requiring concurrent use of 4 or more antihypertensive medications of different classes. Exclusion Criteria: * Patients who meet any of the following criteria will not be permitted entry to the study: * White coat hypertension, ie, elevated BP in the office only, as determined by the Investigator. * Non-adherence to BP medications, as determined by the Investigator. * Systemic glucocorticoid medications exposure (excluding inhalers or topical) within 3 months of screening. For temporary exposures to oral glucocorticoids the Medical Monitor may be consulted to determine eligibility. * Has an historical estimated glomerular filtration rate (eGFR) \< 30. * Has severe untreated sleep apnea as determined by the Investigator. * Has excessive…