Treatment of Bulbar Urethral Strictures With Optilume Drug-Coated Balloons in an Untreated Population

Inclusion Criteria: * Male patients aged 18 years or older. * Diagnosed with a treatment-naive, single bulbar urethral stricture. * Stricture length ≤3 cm. * Eligible for local treatment with paclitaxel. * Able to provide written informed consent. Exclusion Criteria: * Female (chromosomal) sex. * History of prior urethral stricture or prior treatment thereof. * History of hypospadias repair. * History of genital lichen sclerosis. * Active or unresolved confounding etiology, including bladder neck contracture, neurogenic bladder, known or being evaluated for symptomatic benign prostatic hyperplasia (BPH) or surgical treatment for BPH within the last 5 years. * Known allergy or hypersensitivity to paclitaxel or any component of the Optilume DCB. * Known peripheral artery disease. * Severe comorbidities with an American Society of Anesthesiologists (ASA) score of 4 or higher. * Patients unable to comply with follow-up protocols or provide informed consent.