This study investigates the acute effects of Post-Activation Performance Enhancement (PAPE) on the number of repetitions performed to volitional failure and total training volume in resistance-trained men. The research is designed as a randomized crossover trial where participants perform two different exercise protocols under controlled conditions.
The study includes 9 healthy, strength-trained male volunteers aged 18-30 years, with at least one year of resistance training experience. Participants complete two experimental conditions:
PAPE Protocol: A warm-up followed by 3 repetitions at 90% of 1RM, a 10-minute rest, and then 3 sets of half-squat at 75% 1RM until volitional failure.
Control (CON) Protocol: A warm-up followed by 8 repetitions at 50% of 1RM, a 4-minute rest, and then 3 sets of half-squat at 75% 1RM until volitional failure.
The primary outcome measures are:
Total training volume (set × reps × weight) Number of repetitions performed The study aims to determine whether PAPE improves total volume and repetition performance in resistance training. The findings could contribute to better training strategies for athletes and fitness professionals.
Ethical approval was obtained from the Gaziantep University Clinical Research Ethics Committee (Decision No: 2022/373), and all participants provided informed consent before participation.
Who can participate
Age range
18 Years – 30 Years
Sex
MALE
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Participants must be 18-30 years old.
* Only biologically male participants are eligible to participate in the study.
* Participants must have at least 1 year of continuous resistance training experience.
* Participants should be healthy, with no musculoskeletal disorders or injuries in the previous 6 months.
* Participants must have experience in performing the half-squat exercise as part of their regular training routine.
* Participants must be willing to provide written informed consent to participate in the study.
Exclusion Criteria:
* Participants who are currently using performance-enhancing drugs or have a history of chronic drug use.
* Participants with a history of neuromuscular disease, metabolic disorders, hormonal imbalances, cardiovascular diseases, or any orthopedic limitations.
* Participants who are using supplements such as caffeine or any other substances that might interfere with performance or the study protocol.
* Participants who perform high-intensity aerobic training or resistance training outside their routine, which may interfere with study procedures.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Total Training Volume (kg)
Timeframe: Immediately after exercise and 30 minutes post-exercise