Application of Local Melatonin in Peri-implantitis (NCT06816277) | Clinical Trial Compass
CompletedNot Applicable
Application of Local Melatonin in Peri-implantitis
Spain30 participantsStarted 2020-09-01
Plain-language summary
A randomized clinical trial was carried out in patients affected by peri-implantitis with a follow-up of 60 days. Melatonin 1.9 mg or placebo was applied locally to the peri-implant defect after nonsurgical debridement.
To determine the effectiveness anti-inflammatory, osteogenic and antimicrobial properties were evaluated. The probing depth, bleeding index, plaque index, and interleukin-1β and 6 concentrations, peri-implant bone level and the bacterial strains were analyzed.
Who can participate
Age range40 Years – 85 Years
SexALL
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Inclusion criteria:
* Peri-implant disease was recruited according to the criteria of the 2017 World Workshop Classification of Periodontal and Peri-implant Diseases and Conditions.
* Indication for peri-implant surgical treatment.
* One or more fully erupted teeth.
* American Society of Anesthesiologists \[ASA\] Category I and II.
* No history or metabolic or systemic diseases affecting the bone or healing process.
* Agreed to sign informed consent.
Exclusion criteria:
* Tobacco use \>25 cigarettes per day.
* Use of hormonal, anti-inflammatory, corticosteroid, immunosuppressant, analgesic, antidiabetic or antiresorptive medications on a regular or recent basis.
* Pregnant or lactating women.
* Those who refused to participate in the study or did not allow follow-up and sample collection.