The goal of the study is to learn what happens to MK-4482 after single and multiple doses in healthy Chinese participants over time. Researchers also want to learn about the safety of MK-4482, including how well people tolerate it.
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The Maximum Observed Plasma Concentration (Cmax) After Single Oral Dose of MK-4482 in Period 1
Timeframe: At designated time points up to 72 hours post-dose
Time to Reach Maximum Observed Plasma Concentration (Tmax ) After Single Oral Dose of MK-4482 in Period 1.
Timeframe: At designated time points up to 72 hours post-dose
Elimination Half Life (T1/2) After Single Oral Dose of MK-4482 in Period 1
Timeframe: At designated time points up to 72 hours post-dose
Apparent Total Clearance (CL/F) After Single Oral Dose of MK-4482 in Period 1
Timeframe: At designated time points up to 72 hours post-dose
Apparent Volume of Distribution (Vz/F) After Single Oral Dose of MK-4482 in Period 1
Timeframe: At designated time points up to 72 hours post-dose
Area Under the Plasma Concentration-time Curve From Time 0 to 12 Hours Post-dose (AUC0-12hr) After Single Oral Dose of MK-4482 in Period 1
Timeframe: At designated time points up to 72 hours post-dose
Area Under the Plasma Concentration-time Curve From Time Zero to Last Measurable Concentration (AUC0-last) After Single Oral Dose of MK-4482 in Period 1
Timeframe: At designated time points up to 72 hours post-dose
Area Under The Plasma Concentration Versus Time Curve From Time Zero (pre-dose) to Extrapolated Infinite Time (AUC0-inf) After Single Oral Dose of MK-4482 in Period 1
Timeframe: At designated time points up to 72 hours post-dose
The Maximum Observed Plasma Concentration (Cmax) After Multiple Oral Doses of MK-4482 in Period 2
Timeframe: At designated time points up to 72 hours post-dose
Time to Reach Maximum Observed Plasma Concentration (Tmax ) After Multiple Oral Doses of MK-4482 in Period 2
Timeframe: At designated time points up to 72 hours post-dose
Elimination Half Life (T1/2) After Multiple Oral Doses of MK-4482 in Period 2
Timeframe: At designated time points up to 72 hours post-dose
Clearance at Steady State (CLss/F) After Multiple Oral Doses of MK-4482 in Period 2
Timeframe: At designated time points up to 72 hours post-dose
Apparent Volume of Distribution (Vz/F) After Multiple Oral Doses of MK-4482 in Period 2
Timeframe: At designated time points up to 72 hours post-dose
Area Under the Plasma Concentration-time Curve From Time 0 to 12 Hours Post-dose (AUC0-12hr) After Multiple Oral Doses of MK-4482 in Period 2
Timeframe: At designated time points up to 72 hours post-dose
The Minimum Concentration (Ctrough) After Multiple Oral Doses of MK-4482 in Period 2
Timeframe: At designated time points up to 72 hours post-dose
Accumulation Ratio on Cmax After Multiple Oral Doses of MK-4482 in Period 2
Timeframe: At designated time points up to 72 hours post-dose
Accumulation Ratio on AUC0-12hr After Multiple Oral Doses of MK-4482
Timeframe: At designated time points up to 72 hours post-dose