Psilocybin-Assisted Therapy for Physician Well-Being and Burnout (NCT06814522) | Clinical Trial Compass
RecruitingPhase 1/2
Psilocybin-Assisted Therapy for Physician Well-Being and Burnout
United States10 participantsStarted 2025-01-13
Plain-language summary
Through an open-label study involving a small group of UCSD physicians experiencing burnout, the investigators will evaluate the feasibility, safety, and preliminary effectiveness of PAT to reduce burnout symptoms.
Who can participate
Age range21 Years ā 70 Years
SexALL
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Inclusion criteria
ā. UCSD faculty physician, aged 21-70. Volunteer faculty are not included
ā. Meets criteria for physician burnout
ā. Experiencing symptoms of burnout for \>6 months
ā. Able to complete all required study visits
ā. Not previously diagnosed with a serious mental illness (including schizophrenia, bipolar disorder, and severe depression), or substance use disorder as confirmed in clinical interview
ā. Not currently taking any psychotropic medications or nonpsychotropic medication that may be associated with serotonin syndrome, such as serotonin reuptake inhibitors (SSRI or SNRI), dextromethorphan, linezolid, tramadol, meperidine
ā. Previously diagnosed with a psychotic disorder (schizophrenia, schizoaffective disorder, or other psychotic spectrum disorder), bipolar spectrum disorder, personality disorder (borderline personality disorder, antisocial personality disorder, or other severe personality disorders), any severe psychiatric disorder.
ā. Exhibiting elevated suicide risk
ā. First degree family history of psychosis or bipolar disorder
ā. Prior exposure to psilocybin or other psychedelic compounds in the previous 10 years
What they're measuring
1
Stanford Professional Fulfillment Index (PFI)
Timeframe: From enrollment until end of study at 12 week follow-up.
. Currently pregnant, nursing, planning pregnancy, engaging in sexual intercourse without effective contraceptive method in last three months
ā. Those who plan to donate sperm within three months following the study.
ā. Known cardiovascular disease including history of stroke, myocardial infarction, uncontrolled hypertension, valvular heart disease, tachycardia, elongated QT interval, or clinically significant arrythmia.