Treatment of Rectovaginal Crohn's Fistula by Combination of TAAM Injection and Biological Plug Placement

Inclusion Criteria: * Confirmed Crohn's disease * presence of recto-vaginal fistula refractory to standard treatment (surgical drainage of sepsis and treatment with biological drg for at least 12 months) * The patient has received, understood and signed the informed consent to actively participate in the study. * The patient is able to understand the conditions of the study and to participate for the whole duration. Exclusion Criteria: * presence of oostomy * Patients with active HIV, hepatitis C (HCV), hepatitis B (HBV), tuberculosis or other uncontrolled septic conditions. * Patients who present technical difficulties, in the opinion of the investigator, in safely recovering the amount of adipose tissue necessary for the procedure. * Patients with abdominal localization of Crohn's disease who may require general surgery during the study. * Patients with active oncological or lymphoproliferative diseases * Pregnant or breastfeeding women