This is a research study to find out how different people respond to a medication called sitagliptin. Sitagliptin is an FDA approved medication that is used to treat diabetes. We are asking for healthy, non-diabetic volunteers to participate in this 7-week study. If you agree to participate, you will take part in 2 clinic visits that are 4-6 weeks apart. At the clinic visits you will have an oral glucose tolerance test (OGTT) and other blood tests to see how your body processes glucose (sugar). An OGTT is a test in which your drink glucose and then blood samples are taken afterward at specific time points to measure glucose and insulin in your blood. Each clinic visit will last about 5 hours.
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Sitagliptin-induced enhancement of early insulin secretion
Timeframe: 6 weeks
Sitagliptin-induced change in glucose tolerance
Timeframe: 6 weeks