Evaluating Efficacy and Safety of Oral Melatonin in Acute Central Serous Chorioretinopathy (NCT06809751) | Clinical Trial Compass
Not Yet RecruitingPhase 2/3
Evaluating Efficacy and Safety of Oral Melatonin in Acute Central Serous Chorioretinopathy
48 participantsStarted 2025-02-01
Plain-language summary
The goal of this clinical trial is to learn if oral melatonin can enhance visual acuity and central macular thickness in central serous chorioretinopathy (CSCR) in adults. The main questions it aims to answer are:
1. How does melatonin affect central macula thickness in CSCR?
2. How does melatonin affect visual acuity in CSCR? Researchers will compare placebo (a look-like substance that contains no drug) to see if melatonin works to treat CSCR.
Participants will:
1. Take melatonin or placebo twice a day for one month
2. Visit the clinic after finishing a course of treatment, and 1 and 3 months after that for visual acuity assessment and tests
3. Keep a diary of their symptoms
Who can participate
Age range18 Years
SexALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
✓. Patients whose diagnosis of central serous chorioretinopathy is confirmed based on clinical and imaging criteria within the past 6 weeks
✓. Patients with minimum age of 18 years old
✓. Consent to participate in the study
Exclusion criteria
✕. A history of vitrectomy
✕. A history of laser surgery in the eye being studied in the past 3 months
✕. A history of anti-VEGF injection in the eye being studied in the past 3 months
✕. History of patient suspicious for choroidal neovascularization (CNV)
✕. Pregnant or nursing patients
✕. Patients with significantly compromised visual acuity in the eye being studied due to concomitant ocular condition
✕. Patients participating in any other investigational drug study