CompletedNot Applicable

EVALUATION OF SERUM INFLAMMATORY CYTOKINE CONCENTRATION IN HEREDITARY SENSITIVOMOTOR NEUROPATHIES

France85 participantsStarted 2022-05-04

Plain-language summary

The most common forms of hereditary neuropathy are Charcot-Marie-Tooth disease (CMT) and hereditary neuropathy with hypersensitivity to pressure (HNPP) or tomacular neuropathy. A number of patients with one of these pathologies have inflammatory infiltrates in their nerves. Although the pathophysiology has not yet been well understood, the involvement of the immune system has been discussed. Nerve hypertrophy is the main anomaly described in ultrasound in demyelinating hereditary neuropathies and to a lesser extent in axonal forms. Investigators propose to understand if there is a circulating marker of inflammation in patients with CMT or HNPP and find a correlation between the increase in plasma pro-inflammatory cytokines and ultrasound changes.

Who can participate

Age range

18 Years

Sex

ALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria for patients: * Patient over 18 years of age * Patient with CMT of HNPP with genetic confirmation, or acquired acute inflammatory disease such as Guillain-Barré syndrome * Patient able to walk alone or with a walking aid. * Patient affiliated to a social security scheme, * Patient who has given his consent in writing after written and oral information Inclusion Criteria for Healthy Volunteers: * Patient over 18 years of age * Patient affiliated to a social security scheme, * Patient who has given his consent in writing after written and oral information - Exclusion Criteria: * Subject protected by law under guardianship or curators, or not able to participate in a clinical study under article L. 1121-16 of the French Public Health Code; * Subject who has participated in a clinical research study during the last 3 months where he/she was exposed to a pharmaceutical product or medical device; * Subject who has stayed in a tropical or subtropical country during the last 3 months; * Pregnant or breastfeeding subject for women of childbearing age; * Subject who has been physically active for less than 10 hours; * Subject on a particular diet for medical reasons and prescribed by a doctor or dietitian (e.g., low-calorie or cholesterol-lowering diet); * Person who regularly consumes large amounts of alcohol, i.e. more than 50 g of pure alcohol per day (for example, more than 4 glasses of wine 150 ml, more than 4 beers 250 ml, or more than 4 glasses of 40 ml c…

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1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
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What they're measuring

Compare serum interleukin IL-1β between different subgroups of patients with genetic neuropathy (demyelinating/axonal/intermediate Charcot-Marie-Tooth disease (CMT) and hereditary neuropathy with hypersensitivity to pressure (HNPP)) and a control group.

Timeframe: at inclusion

Trial details

NCT IDNCT06808581

SponsorCentre Hospitalier Universitaire de Nice

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2024-10-10

View on ClinicalTrials.gov More Charcot-Marie-Tooth Disease trials