AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* BMI ≥ 40 in the absence of comorbidities; BMI ≥ 35 associated with at least one comorbidity
* Age ≥ 18 and less than or equal to 65 years
* Written informed consent obtained
Exclusion Criteria:
Contraindications to bariatric surgery:
* severe psychiatric illness in the decompensation phase;
* drug or alcohol abuse;
* patient unwilling to follow periodic checkups and a dietary regimen pregnancy or lactation.
Factors that could alter ADH/copeptin:
* Obesity induced by other endocrinopathies or medications;
* Diabetes mellitus of any type;
* Malignant neoplasms or ongoing acute disease;
* Organ failure or chronic CNS and kidney disease;
* Hydro-electrolyte alterations;
* use of drugs that interfere with pituitary-adrenal axis, diuretics, anti-psychotics and psychopharmacological therapies, GLP1 receptor agonists, estro-progestin therapy.
What they're measuring
1
Postoperative Weight Loss and Copeptin Concentration Association
Timeframe: through study completion, an average of 1 year
2
Correlation Between Copeptin Concentration and Thirst Perception
Timeframe: through study completion, an average of 1 year
Trial details
NCT IDNCT06806787
SponsorIRCCS Azienda Ospedaliero-Universitaria di Bologna