RecruitingNot Applicable

Long-term Follow-up (LTFU) Study of Participants in Any iECURE Protocol Using an Investigational Product (IP)

United Kingdom13 participantsStarted 2024-12-23

Plain-language summary

This LTFU is being conducted to assess long-term safety and durability of response in participants dosed with IP in a parent protocol, and to collect longitudinal natural history in enrolled but not dosed participants who also participated in a parent protocol.

Who can participate

Age range

7 Months – 15 Months

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

. Enrolled in an iECURE parent protocol and have either completed or discontinued that protocol
. Participant parent(s)/LAR is willing and able to adhere to the protocol requirements.
. Consent was obtained by the participants parent(s)/LAR (and participant assent, where applicable), prior to any study-related data being collected.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

AE and SAE (incidence, severity, seriousness, and relatedness)

Timeframe: Over 14.5 years post dosing with ECUR-506

Change from baseline over 14.5 years post infusion in length

Timeframe: Over 14.5 years post dosing with ECUR-506

Change from baseline over 14.5 years post infusion in weight

Timeframe: Over 14.5 years post dosing with ECUR-506

Urinalysis (Dip Stick) Evaluations

Timeframe: Over 14.5 years post dosing with ECUR-506

Trial details

NCT IDNCT06805695

SponsoriECURE, Inc.

Sponsor typeINDUSTRY

Study typeOBSERVATIONAL

Primary completion2041-07

Contact for this trial

George Diaz, M.D., Ph.D.

1-877-694-3558 medinfo@iecure.com

View on ClinicalTrials.gov More Ornithine Transcarbamylase Deficiency trials

Who can participate

Age range

7 Months – 15 Months

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

. Enrolled in an iECURE parent protocol and have either completed or discontinued that protocol
. Participant parent(s)/LAR is willing and able to adhere to the protocol requirements.
. Consent was obtained by the participants parent(s)/LAR (and participant assent, where applicable), prior to any study-related data being collected.

What they're measuring

AE and SAE (incidence, severity, seriousness, and relatedness)

Timeframe: Over 14.5 years post dosing with ECUR-506

Change from baseline over 14.5 years post infusion in length

Timeframe: Over 14.5 years post dosing with ECUR-506

Change from baseline over 14.5 years post infusion in weight

Timeframe: Over 14.5 years post dosing with ECUR-506

Urinalysis (Dip Stick) Evaluations

Timeframe: Over 14.5 years post dosing with ECUR-506