A Phase 2 Trial of Ivonescimab for Patients With Advanced, Metastatic Salivary Gland Cancers

Inclusion Criteria: * Participants must have histologically confirmed salivary gland carcinoma (any histologic subtype, including ACC) with evidence of recurrent, metastatic, or advanced, unresectable disease. * Willing to provide tumor tissue from a diagnostic biopsy or prior surgery if deemed safe and feasible by the investigator. * Age 18 years or older at the time of consent. There is no upper age limit restriction in an effort to include patients across the lifespan. * Eastern Cooperative Oncology Group (ECOG) performance status of 0-1. * Participant must have organ and marrow function as defined below within 14 days prior to study registration: * Absolute neutrophil count (ANC) ≥1000/mcL * Hemoglobin ≥8.5 g/dL (with no blood transfusions within 7 days of start of therapy) * Platelets ≥100,000/mcL * Liver function: * Serum total bilirubin (T-bili) ≤1.5× upper limit of normal (ULN); for patients with liver metastases or confirmed/suspected Gilbert syndrome, T-bili ≤3× ULN * Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ≤2.5× ULN; for patients with liver metastases, AST and ALT ≤5× ULN * Creatinine Within normal limits, or Creatinine clearance (CrCl) ≥50 mL/min using the Cockcroft-Gault formula or estimated glomerular filtration rate (eGFR) value ≥50 mL/min using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation (adjustment by BSA is not required for eGFR) * Urine protein: Urine protein \<2+ or 24-hour uri…