Active — Not RecruitingNot Applicable

Energy Metabolism and Acute Effects of Protein Diets in Metabolically Obese Normal Weight Individuals

Singapore24 participantsStarted 2022-02-01

Plain-language summary

Asians tend to develop type 2 diabetes (T2D) at lower body mass index (BMI) levels and younger ages compared to other populations. This leads to a longer duration of suffering from long-term complications associated with the disease, ultimately resulting in shorter life expectancy. Notably, approximately 40% of newly diagnosed T2D cases in Asians occur in individuals considered lean, with a BMI reported to be less than 22 kg/m2. This phenomenon is termed the "Metabolically Obese Normal Weight" (MONW) phenotype. MONW individuals are characterized as having a normal body weight but exhibiting obesity-related metabolic disturbances, including excess body fat with ectopic fat deposition, insulin resistance, and dyslipidemia.

Who can participate

Age range21 Years – 40 Years

SexFEMALE

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Body mass index between 18.5 - 24.9 kg/m2 * Non-diabetic * Blood pressure (≤140/90 mmHg) * \<5% weight change in the past 6 months * Fasting triglyceride \< 90 mg/dl and HOMA-IR ≤ 1.0 will be defined as healthy subjects * Fasting triglyceride ≥ 90 mg/dl and HOMA-IR \> 1.0 will be defined as MONW subjects Exclusion Criteria: * • Smoker or currently on nicotine therapy * Regularly consume alcohol \>1 unit per day * On hypocaloric/hypercaloric diet aiming for weight loss/gain * An athlete or sportive person with regular exercising \>3 times per week and \>45 minutes per section. * Currently receiving therapy (e.g. insulin) or any medication/ treatment (including supplements) that may affect glucose and lipid metabolism, energy metabolism or body composition * Currently on steroids, protease inhibitors, or antipsychotics therapies * Has symptomatic Irritable Bowel Syndrome * Has glucose-6-phosphate dehydrogenase (G6PD) deficiency * Had major medical or surgical event requiring hospitalization within the preceding 3 months * Participated in drug trials within 3 months before the start of the study * Donated blood within 3 months before the start of the study * Has intolerances or allergies to any of the study foods (eg. anaphylaxis to glutens) * Pregnant (pregnancy test will be done), lactating, or planning to be become pregnant during the study period * Has active Tuberculosis (TB) or currently receiving treatment for TB * Has…

What they're measuring

Gycaemic control

Timeframe: Blood will be sampled at timepoints, t = 0minute(fasting), following the meal test,for 4 hours (t = 15, 30, 60, 90, 120, 150, 180 and 240 minutes),and pre- and post-exercise

Energy expenditure and fuel utilization

Timeframe: Assessed for 9 hours in the whole body calorimeter room on visits 3, 4 and 5. 30 minute-RMR,3hour-DIT, 30minute-exercise-induced EE (or PAEE)); urine samples collected on 4 different sessions throughout the WBC

Postprandial amino acids and proteomics profiles

Timeframe: Blood will be sampled at timepoints, t = 0 minute (Baseline) and at t=60 minutes.

Trial details

NCT IDNCT06802341

SponsorSingapore Institute of Food and Biotechnology Innovation

Sponsor typeOTHER_GOV

Study typeINTERVENTIONAL

Primary completion2025-02

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