Clinical Study to Confirm the Safety and Performance of the Virtuoso Phaco-vitrectomy Device

Inclusion Criteria: * Primary or repeat vitrectomy (only applicable to patients scheduled for vitrectomy or combined procedure) * Patients aged ≥ 18 years * Willing and able to provide written informed consent for participation in the study * Willing and able to comply with scheduled visits and other study procedures. Exclusion Criteria: * Patients aged \< 18 years * No post-operative 90 days visit is anticipated * Patients requiring or having already had scleral buckling * Patients with ocular comorbidities affecting surgical view including corneal opacities or scar * Pre-operative endothelial cell count \<1500 cells/cm2 (only applicable to patients considered for the cataract subgroup or the combined surgeries subgroup) * Advanced and secondary glaucoma * History of intraocular inflammation * Untreated diabetes * Microphthalmos or macrophthalmos * Participation in (or current participation) any ophthalmic investigational drug or ophthalmic device trial within the previous 30 days prior to the start date of this trial. * Post-Traumatic eye * Subluxated lens * Morganian cataract * Weak zonules: zonuli lysis or zonula laxa manifest * Pregnant or nursing females