Effectiveness of 3D Bone Matrix in Cranioplasty

Inclusion Criteria: * Patients between 18 and 70 years of age, with acquired skull defect from neurological surgeries such as: * craniocerebral trauma, * refractory intracranial arterial hypertension, * congenital cranial defects such as hydrocephalus or other similar surgically resolvable defects, * who are suitable for reconstruction using a PCL-TCP scaffold system; * patients or their guardians are capable of giving valid informed consent. Exclusion Criteria: * Active infection at the time of study inclusion (in cases of chronic infection, active infections may manifest as a result of a failed trial of antibiotic withdrawal), * immunodeficiency such as: * HIV, * systemic corticosteroid therapy, * chemotherapy, * synchronous hematologic malignancy, * other causes of secondary or primary immunodeficiency; * patients with uncontrolled chronic diseases such ascardiovascular, respiratory or immunological diseases, * psychiatric disorders not controlled with home pharmacotherapy, * Women currently pregnant, breastfeeding or planning to become pregnant within 2 years of reconstruction surgery, * patients with a life expectancy of less than 12 months.