Exercise Rehabilitation in Patients With Severe Cardiopulmonary Dysfunction on Extracorporeal Lif… (NCT06792617) | Clinical Trial Compass
By InvitationEarly Phase 1
Exercise Rehabilitation in Patients With Severe Cardiopulmonary Dysfunction on Extracorporeal Life Support
United States40 participantsStarted 2024-10-25
Plain-language summary
Short-term and long-term consequences of severe cardiac and/or lung dysfunction can be increased use of sedation, prolonged bedrest and immobility causing severe loss of muscle mass which could be a risk for muscle weakness, osteoporosis, and lowered endurance. The goal of this study is to show how a structured rehabilitation program can exhibit better short-term and long-term outcomes on patients who are treated with extracorporeal membrane oxygenation (ECMO).
Who can participate
Age range18 Years
SexALL
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Inclusion criteria
✓. Age \>or equal to 18 years old
✓. On ECMO (VV and/or VA) for cardiopulmonary dysfunction/failure
✓. Admitted to Lung Recovery Intensive Care Unit (LRICU) or Cardiovascular Intensive Care Unit (CVICU).
✓. Richmond Agitation and Sedation Scale (RASS) greater than or equal to a score of -2 or greater.
Exclusion criteria
✕. Hemodynamically unstable as determined by clinical care team (including but not limited to: oxygen saturation \<90%, below target range of mean arterial pressure despite vasoactive or mechanical support, prone positioning, use of mechanical assist device (such as the intra-aortic balloon pump \[IABP\] or ventricular assist device \[VAD\]), active management of intracranial hypertension with abnormal intracranial pressure, spinal precautions, uncontrolled seizures, unstable major fracture, large open surgical wound, known controlled active bleeding).
✕. Unable to utilize the VitalGo Total Lift BedTM (TLB, Catalog No. V5, Miramar FL) (e.g., height restrictions \[\>228 cm\], weight restrictions \[\>425 lbs\])