PCSK9 inhibitoRs for Early Passivation of coRonary athEroSclerotic plaqueS in Acute Coronary Syndromes (REPRESS)

Inclusion Criteria: * Male or female, age ≥ 18 years at screening * Acute coronary syndrome who underwent PCI of the culprit lesions. * Non-culprit vessel (target vessel) meets the following criteria after culprit vessel PCI: * Target vessel diameter \> 2.5 mm, suitable for OCT examination * Target vessel with angiographically estimated stenosis (diameter stenosis 20-70%) * Target vessel must be native coronary arteries, vessel segment without previous PCI * Target vessel cannot be a venous or arterial bridge vessel * Ability to cooperate the requirements of the study and to offer written informed consent * Willingness to complete follow-up visits and examinations as required by the schedule * Life expectancy \> 1 year Exclusion Criteria: * Left main disease of non-culprit artery, defined as ≥ 50% reduction in lumen diameter of the left main coronary artery via angiographic visual estimation * Thrombotic target lesion, severe calcification or tortuosity lesions unfavorable for OCT examination * Coronary artery anatomy that prevents complete imaging of the segment of interest (including at least 5 mm of both edges of the stenosis) * True bifurcation lesions requiring stenting * TIMI flow \< 2 of the culprit-related arteries after PCI * Unstable clinical status (cardiogenic shock, hemodynamic or electrical instability) * Advanced heart failure (New York cardiac class III-IV) * Ischaemic stroke within the past 6 months or cerebral haemorrhage at any time in the past * Severe …