Comparison of RIMA-SVG and Ao-SVG Techniques in Coronary Artery Bypass Grafting (NCT06787651) | Clinical Trial Compass
Active — Not RecruitingNot Applicable
Comparison of RIMA-SVG and Ao-SVG Techniques in Coronary Artery Bypass Grafting
China300 participantsStarted 2025-02-01
Plain-language summary
This randomized, double-blind, single-center clinical trial was divided into two groups, RIMA-SVG and Ao-SVG, according to the surgical method. The purpose was to evaluate the effect of the RIMA-SVG surgical method in improving saphenous vein graft (SVG) patency and reducing clinical complications. A total of 300 patients will be enrolled and randomly assigned to two surgical method groups: RIMA-SVG Group (150 patients): SVGs are connected to the right internal mammary artery (RIMA). Ao-SVG Group (150 patients): The aorta is clamped, and SVGs are connected to the ascending aorta (Ao).All patients will undergo CABG on a beating heart with sequential vein grafts to bypass at least two or more coronary vessels. The primary outcome is 1-year graft patency. The secondary outcomes include neurological complications, mortality, major adverse cardiovascular events (MACE), and surgical site infection event.
Who can participate
Age range18 Years – 80 Years
SexALL
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Inclusion criteria
✓. Patients aged 18 to 80 years.
✓. Scheduled for their first planned coronary artery bypass grafting (CABG) with at least two sequential saphenous vein grafts (SVGs).
✓. Able and willing to provide written informed consent.
Exclusion criteria
✕. Patients unable to provide written informed consent.
✕. Patients requiring other cardiac surgeries (e.g. valve replacement, congenital heart defect surgery, or aortic dissection repair).
✕. Patients with severe stenosis of the left or right subclavian artery.
✕. Patients for whom aortic clamping is infeasible due to calcification of the ascending aorta.
✕. Patients with bilateral SVG varicosities unsuitable for grafting.
✕. Patients with active malignancy.
✕. Patients with active bleeding or a history of bleeding tendency.