This trial is a randomized, double-blind, placebo-controlled, single- and multiple-oral administration, phase 1 clinical trial to investigate the safety, tolerability, and pharmacokinetics of AS-S603 in healthy Korean or Caucasian adults and Korean elderly people. AS-S603 is an orally administered agent developed by Amyloid Solution Inc to treat Alzheimer's disease (AD). It is a small molecule compound that targets and dissolves amyloid-beta (Aβ) and tau aggregates, two key pathologies present in the extracellular and intracellular spaces of brain cells in AD.
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Number of adverse events (AEs)
Timeframe: Up to Day 27
Maximum observed concentration (Cmax)
Timeframe: Up to Day 18
Time of maximum observed concentration (Tmax)
Timeframe: Up to Day 18
Terminal half-life (t1/2)
Timeframe: Up to Day 18
Area under the concentration-time curve from the time of dosing to the time of the last measurable concentration (AUClast)
Timeframe: Up to Day 18
Area under the concentration-time curve from the time of dosing extrapolated to infinity (AUCinf)
Timeframe: Up to Day 18