Ceftriaxone for Post-Treatment Lyme Disease

Inclusion Criteria: * Age 18 to 75 years at the time of consent * Ability and willingness to sign informed consent * Available for the study period * Must have met the definition of a prior well-defined or probable Lyme disease infection, AND meet the definition of PTLDS * Provide consent for release of medical history records and photographs from primary care physician, college or university, urgent care or emergency room visit * Have a level of fatigue that interferes with their ability to function in their job, schooling, or other social/personal activities (FSS score of 4 or higher) * Subjects will need to have been off of antibiotics (those standard antibiotics used to target Lyme disease to include doxycycline, amoxicillin, cefuroxime, azithromycin, ceftriaxone or penicillin) for at least 6 weeks prior to study enrollment and be willing to remain off of any outside antibiotics during the duration of the treatment component of the study. Exclusion Criteria: * Female: pregnant or lactating * Women who intend to become pregnant during the treatment study period (approximately 45 days) * Patients with a diagnosis of Lyme disease based on only a positive Lyme IgM immunoblot * A history of cephalosporin allergy or significant intolerance * Lyme related symptoms that have been present for greater than 10 years * Blood tests confirming infection with human immunodeficiency virus- 1 (HIV-1), hepatitis C, hepatitis B (assessed by HbsAg) virus. Note: Subjects who have well con…