The goal of this clinical trial is to evaluate the safety, tolerability, and pharmacokinetic (PK) profile of FHND1002 granules in healthy adult volunteers. The study will also assess how a high-fat meal affects the PK characteristics of FHND1002. The main questions this study aims to answer are: What are the safety and tolerability of FHND1002 granules when administered as single or multiple doses? What are the PK parameters of FHND1002, and what metabolites can be identified in humans? Participants will: Take FHND1002 granules or a placebo once daily, either as a single dose or for 7 consecutive days. Attend regular clinic visits for checkups, tests, and blood sample collection. Undergo assessments, including monitoring for adverse events, physical exams, vital signs, ECGs, and laboratory tests.
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Peak Plasma Concentration (Cmax)
Timeframe: 4 weeks
Time to Peak Plasma Concentration (Tmax)
Timeframe: 4 weeks
Area Under the Curve from 0 to the Last Quantifiable Time Point (AUClast)
Timeframe: 4 weeks
Area Under the Curve Over the Dosing Interval (AUCÏ„)
Timeframe: 4 weeks
Trough Concentration (Cmin)
Timeframe: 4 weeks
Average Plasma Concentration (Cavg)
Timeframe: 4 weeks
Accumulation Ratio (Rac)
Timeframe: 4 weeks
Elimination Half-life (t1/2)
Timeframe: 4 weeks
Area Under the Curve from 0 to Infinity (AUC0-inf)
Timeframe: 4 weeks
Incidence of Adverse Events(AEs)
Timeframe: 7 weeks
Incidence of Adverse Drug Reactions (ADRs)
Timeframe: 7 weeks