CompletedNot Applicable

Association Between Portal Flow Pulsatility and Right Ventricular Dysfunction in the Postoperative Period of Cardiac Surgery

France32 participantsStarted 2025-02-24

Plain-language summary

Right ventricular dysfunction (RVD) after cardiac surgery is associated with ischemia and myocardial injury. While echocardiographic measures like Tricuspid Annular Plane Systolic Excursion (TAPSE) are frequently used to assess ventricular function, they have limitations in terms of accuracy. The pulmonary artery catheter remains the gold standard for assessing RVD. This dysfunction is associated with an increased risk of both renal and hepatic failure, complications that significantly affect patient outcomes. Doppler ultrasound has emerged as a valuable tool in predicting these complications, particularly in monitoring portal circulation and hepatic perfusion. This study aims to explore the association between portal flow pulsatility and RVD after cardiac surgery.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Patient aged at least 18 years * Patients undergoing cardiac surgery with cardiopulmonary bypass and presenting at least one risk factor for postoperative complications, including: * Patient over 60 years old * Preoperative left ventricular ejection fraction (LVEF) \< 50% * Surgery involving both coronary artery bypass grafting and valve procedures * Mitral valve surgery * Preoperative creatinine clearance less than 30 ml/min * Patient having signed the informed consent form in accordance with regulations * Patient covered by social security or an equivalent healthcare system Exclusion Criteria: * Patient presenting a confounding factor for altered portal flow: * Tricuspid regurgitation greater than grade 2 * Known cirrhosis * Patient with intrahepatic arteriovenous malformations * Patient at risk for pulmonary artery catheter insertion: * Tricuspid valve surgery * Pacemaker or implantable cardioverter-defibrillator in place * Patient with an esophageal tract abnormalities contraindicating transesophageal echocardiography (TEE) * Pregnant or breastfeeding women * Patient unable to understand the information provided * Patient under guardianship, curatorship, or legal protection * Patients deprived of liberty

What they're measuring

Measure of Portal Vein Flow Pulsality

Timeframe: First 24 hours post cardiac surgery

Right ventricular (RV) function assessement

Timeframe: First 24 hours post cardiac surgery

Trial details

NCT IDNCT06777355

SponsorCMC Ambroise Paré

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2025-07-04