Exosomes Proteomic for Sjogren's Syndrome and Dry Eye Syndrome (NCT06771427) | Clinical Trial Compass
RecruitingNot Applicable
Exosomes Proteomic for Sjogren's Syndrome and Dry Eye Syndrome
Taiwan220 participantsStarted 2025-01-16
Plain-language summary
By analyzing the differential proteins in exosomes, this study aims to understand the pathological mechanisms of SJS and DES, identify potential diagnostic and therapeutic methods, and advance the diagnosis and treatment of these diseases.
Who can participate
Age range
20 Years – 75 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Dry eye syndrome
Inclusion Criteria: aged between 20 and 75 years Schirmer's test less than 10 mm/5 min Exclusion Criteria: Pregnancy With eye inflammation or infectious eye disease Accepted operation of eye Sjögren's syndrome
Inclusion Criteria: primary or secondary SS aged between 20 and 75 years fulfilled the 2002 American-European Consensus Criteria for SS (AECG) had no abnormal findings of immune, liver, kidney, or blood function evaluations.
Exclusion Criteria: a history of alcohol abuse, diabetes mellitus, or major life-threatening condition pregnancy or breastfeeding steroid pulse therapy within three months prior to the commencement of our study.
non AIDDES Healthy Controls
Inclusion Criteria: aged between 20 and 75 years without any Chronic disease Exclusion Criteria: any Sjögren's syndrome or Dry eye syndrome.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial is studying exosomes in people with dry eye syndrome and Sjögren's syndrome — can you explain what exosomes are and why analyzing them in my tears or blood might be useful for understanding my condition?
2Since this trial is listed as 'Phase NA,' it sounds like it may be more of an observational or biomarker study rather than a treatment trial — does that mean it wouldn't change what medications or therapies I'm currently receiving, and is there any direct benefit to me as a participant?
3The study is measuring my dry eye severity using the Schirmer's test and the OSDI questionnaire — are those tests I'd be having anyway as part of my standard care, and what would participating in this study involve beyond my usual appointments?
4Given that I have Sjögren's syndrome rather than just dry eye syndrome, would my doctor consider me a good candidate to discuss this trial with, and are there specific features of my condition that might make my participation more or less relevant to what the researchers are trying to learn?
5Before considering this trial, should I make sure my current dry eye and Sjögren's treatments are optimized first, or is this the kind of study where my treatment status doesn't affect whether it makes sense to discuss participation?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.