A Phase III Clinical Trial Evaluating the Efficacy and Safety of Valsartan/Levamlodipine (SYH9056… (NCT06771245) | Clinical Trial Compass
Not Yet RecruitingPhase 3
A Phase III Clinical Trial Evaluating the Efficacy and Safety of Valsartan/Levamlodipine (SYH9056) Tablets In Hypertensive Patients
606 participantsStarted 2025-01-24
Plain-language summary
SYH9056 tablets are a combination of valsartan and levamlodipine maleate. This is a multicenter, randomized, double-blind, parallel-controlled phase III study, designed to validate the efficacy and safety of SYH9056 tablets in patients with mild-to-moderate essential hypertension not controlled after 4 weeks of treatment with either levamlodipine maleate tablets or valsartan capsules, using either levamlodipine maleate tablets or valsartan capsules as a control. The study consisted of 4 phases: a screening period (2 weeks), an introduction period (4 weeks), a core treatment period (12 weeks), an extended treatment period (12 weeks), and a safety follow-up period (1 week), totaling approximately 31 weeks.
Who can participate
Age range18 Years – 75 Years
SexALL
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Inclusion criteria
✓. 18-75 (inclusive) years old;
✓. 18.0 kg/m\^2 ≤ BMI ≤ 35.0 kg/m\^2 and ≥ 50 kg for men and ≥ 45 kg for women at screening;
✓. Diagnosis of mild or moderate essential hypertension;
✓. Office blood pressure measurements meet any of the following at the time of screening:
✓. Prior to randomization, mean office sitting blood pressure meets 140 mmHg ≤ SBP \< 180 mmHg and DBP \< 110 mmHg;
✓. Medication adherence between 80% and 120% (including borderline values) during the introductory period.
Exclusion criteria
✕. Rrefractory hypertension, hypertensive emergencies, hypertensive sub-emergencies and secondary hypertension;
✕. Allergy (≥ 3 drug or food allergies) or known hypersensitivity to levamlodipine, levlevamlodipine, valsartan and related drugs (dihydropyridine calcium channel blockers, angiotensin II receptor blockers);
✕
What they're measuring
1
Absolute change from baseline in mean sitting systolic blood pressure at Week 12
. History of malignancy within the last 5 years (with the exception of cured basal cell carcinoma of the skin, limited squamous cell carcinoma of the skin, or cervical cancer in situ), or an underlying malignancy currently under evaluation;
✕. Known or suspected symptomatic upright/postural hypotension ;
✕. Uncontrolled diabetes mellitus;
✕. Abnormal thyroid function;
✕. Severe cardiovascular or cerebrovascular disease within 6 months prior to screening or randomization.