The goal of this clinical trial is to determine patients' the inflammation and pain response to different apical actions used in rotary instrumentation during root canal shaping process. The main questions it aims to answer are: 1. How the different apical actions of endodontic motors influence the pain and inflammatory mediator release from the periapical region of related tooth? 2. Does the perceived pain differ among the used apical action methods after the root canal preparation? 3. Are the perceived pain and local pain mediator levels coherent? Participants will: Attend to the root canal treatment in the endodontics clinic. The treatment will be two visits. Answer the Visual Analog Scale questionnaire on day 0 (first appt.) and Day 3 (second appt.) Keep a diary of their symptoms and the number of times they use an anti-inflammatory drug.
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Substance P
Timeframe: From Day 0 to Day 3. The last measurement will be taken just before the end of the interventional treatment.