Not Yet RecruitingPhase 3

Nebivolol ANOCA Treatment Randomized Trial

150 participantsStarted 2025-04-01

Plain-language summary

To determine the effectiveness of the beta-blocker nebivolol in controlling symptoms and improving the quality of life in patients with angina and coronary microvascular dysfunction.

Who can participate

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age 18 years or older. * Presence of stable angina symptoms, defined as compatible symptoms occurring at least once weekly in the last three months. * Absence of functionally significant epicardial coronary artery disease (FFR \> 0.80). * Microvascular functional study showing CFR\< 2,0 and/or IMR ≥ 25. Exclusion Criteria: * Allergy or contraindication to the use of beta-blockers. * Indication for beta-blocker treatment due to another pathology. * Ventricular dysfunction (LVEF \< 45%). * Percutaneous coronary revascularization in the last 6 months. * History of surgical revascularization. * First-degree atrioventricular block or bifascicular block. * Presence of hemodynamically significant valvulopathy. * Presence of cardiomyopathy or congenital cardiac anomaly. * Severe renal insufficiency (eGFR \< 30 ml/min). * Liver failure (history of cirrhosis or transaminase elevation \> 3 times the upper limit of normal). * Pregnant or lactating women.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

SAQ questionnaire

Timeframe: 6 months

Trial details

NCT IDNCT06755801

SponsorSpanish Society of Cardiology

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-03-30

Contact for this trial

FERNANDO RIVERO, MD,PHD

+34 915202470. hemodinamicaprincesa@gmail.com

View on ClinicalTrials.gov More ANOCA - Angina With Non-obstructive Coronary Arteries trials

Who can participate

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.