To determine the effectiveness of the beta-blocker nebivolol in controlling symptoms and improving the quality of life in patients with angina and coronary microvascular dysfunction.
Who can participate
SexALL
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Inclusion Criteria:
* Age 18 years or older.
* Presence of stable angina symptoms, defined as compatible symptoms occurring at least once weekly in the last three months.
* Absence of functionally significant epicardial coronary artery disease (FFR \> 0.80).
* Microvascular functional study showing CFR\< 2,0 and/or IMR ≥ 25.
Exclusion Criteria:
* Allergy or contraindication to the use of beta-blockers.
* Indication for beta-blocker treatment due to another pathology.
* Ventricular dysfunction (LVEF \< 45%).
* Percutaneous coronary revascularization in the last 6 months.
* History of surgical revascularization.
* First-degree atrioventricular block or bifascicular block.
* Presence of hemodynamically significant valvulopathy.
* Presence of cardiomyopathy or congenital cardiac anomaly.
* Severe renal insufficiency (eGFR \< 30 ml/min).
* Liver failure (history of cirrhosis or transaminase elevation \> 3 times the upper limit of normal).
* Pregnant or lactating women.