Avexitide for Treatment of Post-Bariatric Hypoglycemia

Inclusion Criteria: * Able to provide written informed consent and understand the purpose and risks of the study * Willing and able to adhere to study requirements, including the use of the study-provided CGM device, SMBG device, and eDiary device as well as the other study evaluations and procedures. * Is male or female, at least 18 years of age (inclusive) at the time of consent. * Body mass index (BMI) of up to 40 kg/m2 and has stable body weight-i.e., not varying by \>5% for at least 2 months prior to Screening * Has undergone documented RYGB performed ≥12 months prior to Screening. * Has clinical diagnosis of PBH-defined as history of recurrent hypoglycemia with onset after surgery and having ruled out other causes of hypoglycemia as per Investigator judgment. * Has recurrent hypoglycemia, as demonstrated by experiencing at least 3 discrete hypoglycemic episodes during the 3-week study Run-in period. * Must agree to consistently follow the dietary management guidance and to maintain consistent exercise and/or physical activity level throughout the Screening period (including the Run-in period), the Double-Blind study treatment period, and Part A of the OLE period. * If female, must meet all of the following: * Is not breastfeeding or lactating; * If of childbearing potential, has negative serum pregnancy test result at Screening and on Day 1 ahead of dosing * If of childbearing potential, must also agree to use a highly effective method of birth control-and agree…