CompletedNot Applicable

Metabolic Effects of the Exercise-metabolite Lac-Phe

Denmark23 participantsStarted 2025-05-13

Plain-language summary

The goal of this double-blinded, randomized cross-over clinical trial is to assess the isolated (i.e. outside the context of exercise) effects of Lac-Phe on appetite and glucose concentrations in healthy volunteers with obesity (BMI 28-35). The main questions it aims to answer are: * Does Lac-Phe reduce appetite in humans? * Does Lac-Phe have glucose-lowering properties in humans? During the study, participants will: * receive an intravenous infusion of Lac-Phe on one study day and a NaCl infusion on another study day. * drink a standard mixed meal * eat an ad libitum meal test * answer appetite questionnaires * indirect calorimetry * blood samples for hormone and substate analyses

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * A body mass index (BMI) between 28-35 kg/m2 * Older than 18 years of age * Hgb within a normal range (females: 7.3-9.5 mmol/L, males: 8.3-10.5 mmol/L) * Females can be included if they are either postmenopausal or actively use hormonal contraception (e.g., oral contraceptive pill or hormone-releasing intrauterine device). Exclusion Criteria: * Medications affecting glucose metabolism (e.g., Saxenda). * Anemia * Diabetes * Ongoing cancer or other acute/chronic serious diseases (PI will determine) * Inability to understand Danish or English * Deemed unsuitable to participate by the PI and co-investigators.

What they're measuring

ad libitum meal test

Timeframe: On the study day, from times 240 minutes and until meal completion as assessed by study participant

Trial details

NCT IDNCT06743009

SponsorUniversity of Aarhus

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-03-10