To date, systemic/local antibiotics, antimicrobials, laser application, and probiotics have been used as adjuncts to improve the outcome of non-surgical periodontal treatment for both periodontitis and peri-implantitis patients. H42® hydrogel, obtained by combining a high molecular weight hydrogel with type I collagen, is a collagen paste for regenerating periodontal/peri-implant pockets caused by periodontitis/peri-implantitis. This study aimed to clinically, biochemically, and radiologically evaluate the effect and reliability of hydrogel application into the pocket in addition to non-surgical periodontal treatment in the treatment of periodontal and peri-implant pockets.
Fifteen patients with stage 2 periodontitis, each with 30 teeth and 30 implants with 5-8 mm pocket depth in the contralateral quadrants, and a total of 30 patients, will be equally divided into two groups. The test group will receive non-surgical periodontal treatment followed by H42 hydrogel application (Hydrogel Oral- 3 syr 0.4 cc/syr), while the control group will receive only non-surgical periodontal treatment. All patients will undergo the same procedure of non-surgical periodontal treatment
Who can participate
Age range18 Years
SexALL
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Inclusion criteria
✓. be over 18 years old
✓. The patient does not have any systemic disease
✓. Patients with a probed pocket depth of 5-8 mm in at least one tooth in the opposite quadrant
✓. According to the 2017 World Workshop on Classification of Periodontal and Peri-Implant Diseases and Conditions, patients of both sexes, aged 25-50 years, diagnosed with stage 2, grade B periodontitis
✓. Patients with clinical loss of attachment of 3-4 mm, bleeding during probing and radiographic horizontal bone loss in the coronal third of the root (15-33%)
✓. Clinical attachment loss of 3-4 mm in \<30% of teeth associated with periodontitis
✓. Patients with a radiographic bone loss/age of 0.25-1 on the tooth with the greatest bone loss in the degree of periodontitis
✓. Patients without anti-inflammatory drug use in the last 2 months
Exclusion criteria
✕. Any systemic disease that may adversely affect the results of treatment (receiving radiotherapy and chemotherapy, systemic bisphosphonate, and corticosteroid use) to be found
What they're measuring
1
Periodontal or peri-implant pocket depth
Timeframe: 3-month follow-up of all implants and teeth
2
Proinflammatory markers
Timeframe: 3-month follow-up of all implants and teeth
3
Marginal bone level change
Timeframe: 6-month follow-up of all implants and teeth