CompletedNot Applicable

Dietary Supplementation on Tear Secretion and Inflammation in DES

Taiwan52 participantsStarted 2021-09-27

Plain-language summary

The goal of this clinical trial is to explore the effect of supplementation of fish oil, lutein and zeaxanthin on the symptoms of dry eye syndrome, antioxidant capacity, oxidative stress and anti-inflammatory capacity in DES patients., it aims to answer are: To evaluate the effects of a 12-week multicomponent dietary supplementation (capsule content are eicosapentaenoic acid 45 mg, docosahexaenoic acid 30 mg, lutein 30 mg, and zeaxanthin1.8 mg)on symptoms of dry eye syndrome, oxidative stress, antioxidant capacity, and inflammation. To investigate the relationships between dry eye symptoms, oxidative stress, antioxidant capacity, and inflammation. Participants will be randomly assigned to control group (n = 50) and supplement group (n = 50) and white pomegranate extract group (n = 50) for 12 weeks. Participants will complete assessments of tear secretion, antioxidant capacity, and ocular surface inflammation.

Who can participate

Age range

20 Years – 80 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

. aged between 20 and 80 years,
. moderate or above severity of dry eye syndrome.

Exclusion criteria

. undergoing ophthalmic surgery within the past three months,
. autoimmune diseases,
. ocular allergies,
. consumption of fish oil or antioxidant supplements within the past three months, and
. pregnant or lactating women.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1This trial looked at dietary supplementation for dry eye syndrome and measured the Ocular Surface Disease Index — can you explain what that index measures and whether my current dry eye symptoms would have been captured by it?
2Since this trial is already completed, has any data or results been published that you've seen, and do they suggest the supplement used might be relevant to my treatment plan?
3The trial is listed as Phase NA, which sometimes means it's more of an observational or nutritional study rather than a drug trial — does that affect how confident we can be in the safety and effectiveness of what was tested?
4Are there standard dry eye treatments I should try first before considering anything based on this kind of dietary supplement research, or could a supplement approach make sense to explore alongside my current care?
5If the results from this trial look promising, is there a specific type of specialist — like a cornea or ocular surface expert — who would be best placed to help me interpret whether those findings apply to my situation?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Ocular Surface Disease Index

Timeframe: 12 weeks

Trial details

NCT IDNCT06738446

SponsorShih Chien Huang

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2022-04-02

View on ClinicalTrials.gov More Dry Eye Syndrome (DES) trials