The study will investigate the Pharmacokinetic (PK), Pharmacodynamic (PD), the safety and tolerability of AZD4604, as well as to examine the effect of Fractional exhaled Nitric Oxide (FeNO) following the administration of the multiple doses of AZD4604 via Turbuhaler device.
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Maximum observed drug concentration (Cmax) of AZD4604
Timeframe: Day 9 (Pre-dose) and Day 10 (Pre-dose and Post-dose)
Time to reach maximum observed concentration (tmax) of AZD4604
Timeframe: Day 9 (Pre-dose) and Day 10 (Pre-dose and Post-dose)
Area under concentration-time curve in the dosing interval (AUCtau) of AZD4604
Timeframe: Day 9 (Pre-dose) and Day 10 (Pre-dose and Post-dose)
Apparent total body clearance (CL/F) of AZD4604
Timeframe: Day 10 (Pre-dose and Post-dose)
Apparent volume of distribution based on the terminal phase (VZ/F) of AZD4604
Timeframe: Day 10 (Pre-dose and Post-dose)
Dose normalised AUCtau (AUCtau/D) of AZD4604
Timeframe: Day 9 (Pre-dose) and Day 10 (Pre-dose and Post-dose)
Dose normalised Cmax (Cmax/D) of AZD4604
Timeframe: Day 9 (Pre-dose) and Day 10 (Pre-dose and Post-dose)