Personalized Dual-target RTMS for Patients with Refractory Schizophrenia (NCT06732817) | Clinical Trial Compass
CompletedNot Applicable
Personalized Dual-target RTMS for Patients with Refractory Schizophrenia
China20 participantsStarted 2023-04-01
Plain-language summary
The goal of this clinical trial is to evaluate the efficacy of personalized dual-target rTMS for treating patients with refractory schizophrenia and to investigate its underlying neural mechanisms using functional MRI.
The main questions it seeks to address are:
Does the dual-target rTMS protocol improve clinical symptoms in patients with refractory schizophrenia? What neural circuit changes, as assessed by functional MRI, occur following rTMS treatment?
Participants will:
Undergo personalized, dual-target rTMS treatment daily for 3 weeks. Complete baseline and post-treatment assessments, including clinical symptom scales (PANSS, HAMA, HAMD) and neuropsychological tests (MoCA, DST, VFT, Stroop Test, and AVLT).
Have structural and resting-state functional MRI scans before and after treatment.
Be monitored for any treatment-related adverse events.
Who can participate
Age range18 Years – 60 Years
SexALL
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Inclusion criteria
✓. diagnosed by independent psychiatrists using the Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders, 4th Edition;
✓. disease duration longer than six years;
✓. hospitalization two or more times;
✓. aged 18-60 years;
✓. a stable dosage of antipsychotic medication for at least four weeks before inclusion, and retention of this stable dose for the duration of the study.
Exclusion criteria
✕. accompanied by other mental illnesses or histories;
✕. pregnant;
✕. a history of severe head trauma or neurological disease;
✕. focal brain lesions on T1- or T2-weighted fluid-attenuated inversion-recovery MRI;
✕. a history of rTMS or electroconvulsive therapy in the six months prior to the study; and